Dialysis is a procedure to remove waste products and excess fluid from the blood when the kidneys stop working properly. It often involves diverting blood to a machine to be cleaned.

In haemodialysis, blood is removed from the body and filtered through a man-made membrane called a dialyzer, or artificial kidney, and then the filtered blood is returned to the body

Dialysate, also called dialysis fluid, dialysis solution or bath, is a solution of pure water, electrolytes and salts, such as bicarbonate and sodium. The purpose of dialysate is to pull toxins from the blood into the dialysate. The way this works is through a process called diffusion.

CaCl in Dialysis

The dialysate calcium (Ca) concentration for hemodialysis (HD) patients can be adjusted to manage more optimally the body’s Ca and phosphate balance, and thus improve bone metabolism as well as reduce accelerated arteriosclerosis and cardiovascular mortality. The appropriate dialysate Ca concentration allowing this balance should be prescribed to each individual patient depending on a multitude of variable factors relating to Ca load.


Standard dialysis solutions have historically used glucose or its hydrated form, dextrose, as a crystalloid osmotic agent; An active ions or molecules that are poorly absorbed by the intestine and thereby obligate water retention intraluminally to maintain isotonicity with plasma. These fluids have been shown to be safe, effective, readily metabolized, and inexpensive.


Magnesium Chloride Hexahydrate, Potassium Chloride, and Sodium Chloride are clinically approved compounds to derived Biphozyl.

As a solution for haemodialysis/ haemofiltration, Biphozyl is indicated as replacement solution and as dialysis solution for treatment of acute kidney injury during continuous renal replacement therapy (CRRT). Biphozyl is used in a post-acute phase after initiation of renal replacement therapy when pH, potassium and phosphate concentration have returned to normal. Biphozyl is also used when other buffer sources are available as well as during regional citrate anticoagulation.

Moreover, Biphozyl is used in patients with hypercalcaemia.

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